Abstracts

Organoids are 3D cellular structures for organ modeling and drug testing. Retinal organoids are needed to study diseases like retinoblastoma; however, their development is particularly difficult. To form inner retina cells, the organoids need to be in a hypoxic state, yet the outer retina cells cons...

Fluorescence recovery after photobleaching (FRAP) is a technique that uses a confocal microscope to study the diffusion of molecules within a membrane. During FRAP, fluorescently-labeled molecules within a specified region of interest (ROI) are photobleached using a high-power laser. After photoblea...

Achieving greening in a supply chain substantially depends on the structure of the channel and the efforts of independent members of the chain whose incentives may not be aligned. To investigate these two critical factors, we study a two-echelon green supply chain composed of a single supplier and a...

The project's overall objective is to study afferent nociceptor activity in the corneas of transgenicmice as a novel method for studying oral cancer pain. Using a scanning laser confocal for Ca2+imaging in vivo, we will assess the change in fluorescence of Ca-reporter GCaMP3 expressingsensory neuron...

Pancreatic islet microencapsulation and localized delivery of immunomodulatory molecules may improve islet transplantation outcomes in type-1 diabetes (T1D) patients by preventing allograft rejection and maintaining metabolic control without chronic and systemic immunosuppression. Here, we encapsula...

Type I diabetes (T1D) results from T cell destruction of pancreatic beta-cells that leads to insulin ablation. Autoimmune attacks on beta cells occur, due to defective immune tolerance and escape of autoreactive T cells from regulation. There is no cure available for T1D, and patients rely on exogen...

Objectives:RECOVER is an ongoing, prospective cohort study inviting first responders, healthcare workers, and other frontline workers to complete weekly surveys and RT-PCR C19 testing. Enrollment surveys inquire about the percentage of time face masks are worn outside of work, allowing us to address...

Disease modelling is an extremely powerful tool that provides insight to disease pathology in areas of the body that cannot be easily studied. 3D Organoid culture has become a hallmark in disease modelling, especially for specialized tissues of the brain which are impossible to study at the cellular...

Gelatin scaffolds that mimic the structure of the Lymph Nodes (LN) can assist in studying the influence of Fibroblastic Reticular Cells, supportive cells in the LN, on peripheral tolerance in Type I diabetes. We fabricated freeze-dried gelatin scaffolds crosslinked with glutaraldehyde using various ...